| 标题 | 杂志 | 摘要 |
Antisense directed at the Ah region of APP decreases brain oxidative markers in aged senescence accelerated mice |
Brain Res. 2021年01月 Poon HF, et al. |
Therefore, we conclude that Abeta may contribute to the oxidative stress found in aged SAMP8 mice that have learning and memory impairments. These results are discussed in reference to AD. |
Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders |
Neurochem Int. 2021年01月 Poon HF, et al. |
These findings suggest that the improved learning and memory observed in LA-injected SAMP8 mice may be related to the restoration of the normal condition of specific proteins in aged SAMP8 mouse brain. |
Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat |
Brain Res Mol Brain Res. 2021年01月 Pocernich CB, Poon HF, et al. |
These results are discussed with reference to potential involvement of these proteins in HIV dementia and protection of astrocytes against oxidative stress by the HIV virus, a prerequisite for survival of a viral host cell. |
Proteomics analysis of human astrocytes expressing the HIV protein Tat |
Brain Res Mol Brain Res. 2021年01月 Pocernich CB, Poon HF, et al. |
These findings are discussed with reference to astrocytes serving as a reservoir for the HIV virus and how Tat promotes survival of the astrocytic host. |
The antioxidants a-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice |
J Neurochem. 2021年01月 Farr SA, Poon HF, et al. |
These results support the hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants. |