Biol Proced Online.

2021年01月

Poon HF, et al.

The methodology highlighted here may be useful in facilitating the development of biomarkers, assessing potential therapeutic targets and elucidating new mechanisms of redox signalling in redox-related conditions.

Sport Sci Health.

2021年01月

Poon HF, et al.

These results suggest that altered protein redox state occurs while running an exhausting run in relation to the physical condition of the subjects involved.

Sport Sci Health.

2021年01月

Poon HF, et al.

These results suggest that altered protein redox state occurs while running an exhausting run in relation to the physical condition of the subjects involved.

Neurobiol Dis.

2021年01月

Butterfield AD, Poon HF, et al.

We conclude that protein oxidation plays a significant role in the development of AD from MCI and that the oxidative inactivation of ENO1, GLUL, PKM2 and PIN1 is involved in the progression of AD from MCI. The current study provides a framework for future studies on the development of AD from MCI relevant to oxidative stress.

Neurobiol Aging.

2021年01月

Poon HF, et al.

These results were validated by immunochemistry. In addition, enzyme activity assays demonstrated that oxidation was associated with decreased GS activity, while the activity of lactate dehydrogenase was unchanged in spite of an up-regulation of LDH2 levels. Several of the up-regulated and oxidized proteins in the brains of old mice identified in this report are known to be oxidized in neurodegenerative diseases as well, suggesting that these proteins may be particularly susceptible to processes associated with neurodegeneration.

Neurotox Res.

2021年01月

Langer A, Poon HF, et al.

Based on results from prior studies, modification of these proteins may lead to a loss of function. Consequently, the identification of targets for these proteins is of particular interest for a better understanding of the consequences of AGE-modification in aging, neurodegenerative diseases and diabetes.