| 标题 | 杂志 | 摘要 |
Degradation of biotherapeutics during manufacturing processes and its solution |
J Int Pharm Res. 2021年01月 Fang WJ, Poon HF, et al. |
This review summarizes major factors that affect the degradation of biotherapeutics during manufacturing processes and proposes corresponding so⁃ lutions in each step of the manufacturing process. |
Skeletal muscle and hepatic insulin signaling is maintained in heat-stressed lactating Holstein cows |
J Dairy Sci. 2021年01月 Xie G, et al. |
These results indicate that mild systemic insulin resistance during HS may be related to reduced nutrient intake but skeletal muscle and liver insulin signaling remains unchanged. |
Galactose supplementation enhance sialylation of recombinant Fc-fusion protein in CHO cell: an insight into the role of galactosylation in sialylation |
World J Microbiol Biotechnol. 2021年01月 Liu J, Poon HF, et al. |
These data together show that the galactosylation plays an apparent role in sialylation in our current system. |
Alteration of Digestive Tract Microbiome in Neo-natal Holstein Bull Calves by Bacitracin Methylene Diasalicylate Treatment and Scours. |
J Anim Sci. 2021年01月 Xie G,et al. |
These results show that BMD has the ability to alter the composition of the fecal microbiome but failed to improve performance in Holstein bull calves. Discrepancy of microorganism profiles between scouring and nonscouring calves might be associated with the occurrence of scours and bacterial genera identified might be potential target of treating diarrhea. |
Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer’s Disease Brain and in Brain from a Rodent Model of Familial Parkinson’s Disease: Insights into Potent Mechanisms of Neurodegeneration |
In book 2021年01月 Sultana R, Poon HF, et al. |
Advances in Alzheimer’s and Parkinson’s Disease (pp.149-167) |
Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Inherited Alzheimer's Disease: An Initial Assessment |
J Alzheimers Dis. 2021年01月 Butterfield AD, Poon HF, et al. |
Results: An initial redox proteomics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), gamma-enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. |